![]() ![]() The same trend was observed with decreased levels in the tertiles for the end-tidal-to-arterial PCO 2 ratio. As ARDS severity increased, mortality increased with successive tertiles of dead space fraction by Harris–Benedict and by direct estimation, and with an increase in the VR. The end-tidal-to-arterial PCO 2 ratio was lower in non-survivors than in survivors ( p < 0.001). Estimations of wasted ventilation such as the estimated dead space fraction (by Harris–Benedict and direct method) and ventilatory ratio were significantly higher in non-survivors than survivors at baseline and during the following days of mechanical ventilation ( p < 0.001). ResultsĪ total of 927 consecutive patients admitted with COVID-19-related ARDS were included in this study. The aim was to quantify the dynamics and determine the prognostic value of surrogate markers of wasted ventilation in patients with COVID-19-related ARDS. Consecutive patients aged at least 18 years were eligible for participation if they had received invasive ventilation for COVID-19 at a participating ICU during the first month of the national outbreak in the Netherlands. The PRoVENT-COVID is a national, multicenter, retrospective observational study done at 22 intensive care units in the Netherlands. Secondary analysis from the PRoVENT-COVID study. ![]() ![]() Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS. ![]()
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